So you’ve heard of skin boosters – now meet their advanced cousin: Polynucleotides. Rapidly gaining popularity across the UK, these regenerative injectables are becoming a go-to for clients looking to heal, revive, and strengthen their skin from within.
What Are Polynucleotides?
Polynucleotides are biostimulating molecules made from highly purified fragments of DNA (usually derived from salmon or trout). When injected into the skin, they work by:
Stimulating cell regeneration
Reducing inflammation
Improving skin elasticity
Enhancing hydration naturally
Unlike dermal fillers, they don’t add volume – instead, they train your skin to repair itself and become healthier over time. Amazing right?
What Variations Are There?
There are a few leading brands of polynucleotide-based treatments in the UK, each tailored for different areas and concerns:
- Plinest – Often used for delicate areas like under the eyes.
- Newest – Designed for overall facial rejuvenation.
- PhilArt – Targets skin quality, firmness, and fine lines.
- Croma PDRN – Known for treating compromised or inflamed skin.
Most polynucleotide treatments are used in courses of 2–3 sessions, spaced a few weeks apart, with results building gradually over time. At Tweaks, we will learn your skint type and hear your struggles and then tailor as needed.
What Do They Treat or Help With?
Polynucleotides are particularly effective for:
- Fine lines and crepey texture
- Acne scars and post-inflammatory pigmentation
- Under-eye hollows and dark circles
- Redness, inflammation, and rosacea-prone skin
- Overall dull, dehydrated, or ‘tired’ skin
They’re also beneficial post-procedure (e.g., after microneedling or laser) to speed up healing and reduce inflammation.
Are Polynucleotides Right For You?
Polynucleotides are ideal if you:
✅ Have sensitive, inflamed, or stressed skin
✅ Struggle with acne scarring, dark circles, or crepey texture
✅ Want more than just hydration – you want long-term repair
✅ Are looking for a natural alternative to fillers
Your practitioner will assess your skin and goals to recommend the right product and plan. Often, polynucleotides can be combined with other treatments like microneedling or radiofrequency for enhanced results.
So… how do they differ from Skin Boosters?
While both skin boosters and polynucleotides aim to improve skin quality, they work in very different ways. Skin boosters are typically made with hyaluronic acid and focus on deep hydration, giving the skin an instant glow and plumper appearance.
Polynucleotides, on the other hand, go deeper – they’re DNA fragments that encourage your skin to regenerate, repair, and rebuild itself over time. Rather than a quick fix, polynucleotides are ideal for those wanting longer-term skin health improvements, especially if your concerns involve inflammation, scarring, or a weakened skin barrier. Think of skin boosters as your go-to for hydration and radiance, while polynucleotides are your long-term investment in stronger, healthier skin
To Summarise
Polynucleotides are one of the most exciting innovations in skin health – not just treating symptoms, but supporting your skin’s natural ability to heal and thrive. If you’re curious whether they’re the right option for you, we offer free consultations to guide you through your personalised skin journey.
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